Table 4. Associations between DNAm age and cognitive functioning, by AD status.

	Non-Demented Participants (n=397)			AD Participants (n=303)
	β (SE)	P-value	β (SE)	P-value
GCF	−0.059 (0.503)	0.454	−0.500 (0.210)	0.009
EM	−0.209 (0.322)	0.258	−0.411 (0.173)	0.009
WM	0.340 (0.328)	0.836	−0.405 (0.177)	0.011
SM	−0.047 (0.429)	0.456	−0.262 (0.160)	0.051
PO	−0.049 (0.312)	0.437	−0.102 (0.210)	0.313
PS	−0.058 (0.304)	0.425	−0.178 (0.205)	0.193

DNAm age was used as the dependent variable for all models. All models were run adjusting for study (ROS or MAP), age at death, age a clinical evaluation, and sex. GCF=Global Cognitive Functioning, EM=Episodic Memory, WM=Working Memory. P-values represent significance assuming a one-tailed hypothesis test. Standard errors were adjusted via clustering by Sample ID, in order to account for multiple observations.