Figure 5. Cross-generalization between orally supplied taste stimuli and photostimulation of the sweet cortex.

a, Representative histograms illustrating mouse performance during a training session in the go/no-go discrimination task. The mouse was trained to go to bitter (0.5 mM quinine) and low-salt (20 mM NaCl), and no-go to sweet (4 mM AceK). Note that both bitter (aversive) and low salt (attractive) were used in the same branch of the behavioral task (go) to exclude the valence as an identifier. b, Left, representative histograms illustrating cross-generalization between taste stimulation and photostimulation of the sweet cortical field. Right, quantitation of the responses from individual animals to quinine, AceK, salt and salt + light (n = 8, Mann-Whitney U test, P < 0.0002).