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Survival of NREM and REM sleep bouts changes after discontinuation of DOX. After DOX removal, survival of NREM sleep bouts decreases in the dark period (A) (log-rank test, P < 0.01) but not in the light period (B). In contrast, in the weeks after DOX discontinuation, survival of REM sleep bouts clearly increases in the dark period (log-rank test, P < 0.01) (C) and increases to a lesser extent in the light period (log-rank test, P < 0.05) (D).
