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. Author manuscript; available in PMC: 2016 Jan 14.

Published in final edited form as: Virology. 2015 Oct 1;486:116–120. doi: 10.1016/j.virol.2015.08.002

Table 2.

Summary of EC₅₀ values (in ng/ml) derived from D7324-capture ELISA with different SOSIP.664 trimers.

For comparison, midpoint neutralization concentrations (IC₅₀ in ng/ml) of the sequence-matched Env-peudotyped viruses are also indicated.

		BG505			B41			ZM197m
		SOSIP.664		pseudovirus	SOSIP.664		pseudovirus	SOSIP.664		pseudovirus

		Germline	Mature	Mature	Germline	Mature	Mature	Germline	Mature	Mature

V1V2 apex	PG9	935	40	45^*	>25000	242	560 ^*	6769	103	393^*
	PG16	13100	31	8^*	>25000	65	80 ^*	>25000	77	49^*
	PGT145	>25000	12	83^*	>25000	67	60	>25000	27	393^*
	VRC26.09	>25000	31	<10	>25000	1204	>25000	>25000	50	4^*
	CH01	640	58	301^*	1003	44	N.D.	>25000	2044	N.D.

CD4bs	VRC01	>25000	9	70^*	>25000	34	1380 ^*	>25000	7	329^*
	3BNC60	>25000	21	34 ^*	>25000	55	11	>25000	58	77
	1NC9	>25000	209	251^*	>25000	355	1961	>25000	128	1006^*
	CH103	>25000	179	2572^*	>25000	2412	>25000	18090	143	18222
	CH31	>25000	13	14^*	>25000	32	26	>25000	48	358

gp41 and interface	PGT121	>25000	61	15^*	>25000	147	920 ^*	>25000	35	35^*
gp41 and interface	PGT128	>25000	12	11^*	>25000	46	414	>25000	6	33^*

V3 glycan	PGT151	>25000	28	1	>25000	126	300 ^*	>25000	30	2^*
	35O22	>25000	379	8	>25000	1052	>25000	>25000	463	2816^*
	3BC315	538	144	1259 ^*	>25000	102	>25000	266	124	3549^*

graphic file with name nihms749754u1.jpg

^*

IC₅₀ values obtained from (Sanders et al., 2013) for BG505; (Pugach et al., 2015) for B41; (Julien et al., in press) for ZM197M

N.D.: not determined