Table 1.

Compartment models and their pharmacokinetic parameters and respective units as implemented in our software. Please note that Ktrans = E*Fp and, for the ETM, by definition PS = Ktrans

	Plasma Flow (Fp) (ml/min/100 ml)	Plasma MTT (s)	Plasma Volume (ml/100 ml)	Interstitial MTT (s)	Interstitial Volume (ml/100 ml)	Extraction Fraction (E) (%)	Permeability-surface area product (PS) (ml/min/100 ml)	Ktrans (ml/min/100 ml)
1CP	x	x	x
2CUM	x	x	x			x	x	x
2CFM	x	x	x	x		x	x	x
2CXM	x	x	x	x	x	x	x	x
ETM			x	x	x		x	x