Table 3.
Frequent chromosome losses and gains involving single genes
| Number of samples | Type | Chromo some | Band | Gene | miRNA | GV |
|---|---|---|---|---|---|---|
| 7 | Gain | 7 | p11.2 | EGFR | - | |
| 7 | Gain | 1 | p36.32 | PRDM16 | hsa-mir-551ahsa-mir-551a | v |
| 7 | Loss | 12 | q24.13 | PTPN11 | - | |
| 7 | Gain | 2 | q31.1 | HOXD11, HOXD13 HOHOHOXD13 HOXD11HOXD13 | v | |
| 6 | Loss | 13 | q12.2 | FLT3 | - | |
| 6 | Gain | 9 | q22.32 | PTCH | v | |
| 5 | Loss | 8 | p11.22 | FGFR1 | - | |
| 5 | Loss | 3 | p13 | FOXP1 | - | |
| 5 | Gain | X | q26.2 | GPC3 | - | |
| 5 | Gain | 12 | q13.13 | HOXC13, HOXC11 | hsa-mir-196a-2 | v |
| 5 | Loss | 22 | q13.1 | MKL1 | v | |
| 5 | Loss | 22 | q12.1 | CHEK2 | v |
The column “Number of samples” represents the number of patients with a particular genomic abnormality. For each variation the type of variation (gain or loss), location on chromosome and band, the gene located in this locus and miRNAs located in this locus are enlisted. Variants reported in the Database of Genomic Variants (DGV) database in genes are denoted as “v” and if none reported as “-” under the column DGV