Table 2.
Correlations between the genotype frequencies of the polymorphisms and the family history of cancer (overall)
| Number of cancer cases | Presence of bilateral breast cancer | Presence of ovarian cancer | Number of generations with cancer | Number of breast cancer cases | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polymorphism | ≤3 | >3 | Yes | No | Yes | No | 1 | 2 | 3 | 4 | ≤3 | >3 |
| rs3803662 – TT | 13 | 21 | 4 | 30 | 4 | 30 | 8 | 17 | 8 | 1 | 25 | 9 |
| N (%) | (20.0) | (15.3) | (20.0) | (16.5) | (14.3) | (17.2) | (22.2) | (17.9) | (12.5) | (16.7) | (17.6) | (15.3) |
| rs3803662 - TC | 25 | 73 | 9 | 89 | 15 | 83 | 15 | 44 | 35 | 4 | 63 | 34 |
| N (%) | (38.5) | (53.3) | (45.0) | (48.9) | (53.6) | (47.7) | (41.7) | (46.3) | (54.7) | (66.7) | (44.4) | (57.6) |
| rs3803662 - CC | 27 | 43 | 7 | 63 | 9 | 61 | 13 | 34 | 21 | 1 | 54 | 16 |
| N (%) | (41.5) | (31.4) | (35.0) | (34.6) | (32.1) | (35.1) | (36.1) | (35.8) | (32.8) | (16.7) | (38.0) | (27.1) |
| Total N (%) | 65 (100.0) | 137 (100.0) | 20 (100.0) | 182 (100) | 28 (100) | 245 (100.0) | 36 (100) | 95 (100) | 64 (100) | 6 (100) | 142 (100) | 59 (100) |
| P value a | (p = 0.602) | (p = 0.849) | (p = 0.998) | (p = 0.890) | (p = 0.429) | |||||||
| rs2981582 - TT | 17 | 32 | 4 | 45 | 2 | 47 | 6 | 28 | 12 | 3 | 33 | 15 |
| N (%) | (25.8) | (23.2) | (20.0) | (24.5) | (7.5) | (26.6) | (10.7) | (29,5) | (18,2) | (50,0) | (23,1) | (25,0) |
| rs2981582 - TC | 28 | 76 | 13 | 91 | 18 | 86 | 16 | 44 | 42 | 1 | 70 | 34 |
| N (%) | (42.4) | (55.1) | (65.0) | (49.5) | (66.6) | (48.6) | (44.4) | (46.3) | (63.6) | (16.7) | (59.0) | (56.7) |
| rs2981582 - CC | 21 | 30 | 3 | 48 | 7 | 44 | 14 | 23 | 12 | 2 | 40 | 11 |
| N (%) | (31.8) | (21.7) | (15.0) | (26.1) | (25.9) | (24.9) | (38.9) | (24,2) | (18.2) | (33.3) | (28.0) | (18.3) |
| Total N (%) | 120 | 156 | 20 | 184 | 27 | 177 | 36 | 95 | 66 | 6 | 143 | 60 |
| (100.0) | (100) | (100.0) | (100) | (100) | (100.0) | (100) | (100) | (100) | (100) | (100) | (100) | |
| P value a | (p = 0.475) | (p = 0.688) | (p = 0.163) | (p = 0.172) | (p = 0.283) | |||||||
| rs13281615 - AA | 21 | 31 | 3 | 49 | 11 | 41 | 14 | 22 | 16 | 0 | 37 | 15 |
| N (%) | (31.8) | (22.3) | (15.0) | (26.5) | (39.3) | (23.2) | (38.9) | (23.2) | (23.9) | (0.0) | (25.7) | (25.0) |
| rs13281615 - AG | 37 | 61 | 5 | 93 | 12 | 86 | 16 | 51 | 27 | 3 | 70 | 27 |
| N (%) | (56.1) | (43.9) | (25.0) | (50.3) | (42.8) | (48.6) | (44.4) | (53.7) | (40.3) | (50.0) | (48.6) | (45.0) |
| rs13281615 -GG | 8 | 47 | 12 | 43 | 5 | 50 | 6 | 22 | 24 | 3 | 37 | 18 |
| N (%) | (12.1) | (33.8) | (60.0) | (23.2) | (17.9) | (28.2) | (16.7) | (23,2) | (35.8) | (50.0) | (25.7) | (30.0) |
| Total N (%) | 66 | 139 | 20 | 185 | 28 | 177 | 36 | 95 | 67 | 6 | 144 | 60 |
| (100) | (100) | (100.0) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | |
| P value a | 0.004 | 0.005 | 0.072 | 0.007 | 0.654 | |||||||
| N (%) | (16.7) | (11.5) | (25.0) | (11.9) | (7.1) | (14.1) | (11.1) | (14.7) | (13.4) | (0.0) | (14.6) | (10.0) |
| rs889312 - CA | 28 | 68 | 12 | 84 | 12 | 84 | 18 | 36 | 36 | 5 | 66 | 30 |
| N (%) | (42.4) | (48.9) | (60.0) | (45.4) | (42.9) | (47.5) | (50.0) | (37.9) | (53.7) | (83.3) | (45.8) | (50.0) |
| rs889312 - AA | 27 | 55 | 3 | 79 | 14 | 68 | 14 | 45 | 22 | 1 | 57 | 24 |
| N (%) | (40.9) | (39.6) | (15.0) | (42.7) | (50.0) | (38.4) | (38.9) | (47.4) | (32.8) | (16.7) | (39.6) | (40.0) |
| Total N (%) | 66 (100) | 139 | 20 | 185 | 28 | 177 | 36 | 95 | 67 | 6 | 144 | 60 |
| (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | ||
| P value a | 0.707 | 0.011 | 0.179 | 0.373 | 0.632 | |||||||
| rs3817198 - TT | 31 | 67 | 6 | 92 | 18 | 80 | 21 | 41 | 33 | 2 | 70 | 28 |
| N (%) | (47.0) | (48.6) | (30.0) | (50.0) | (66.7) | (45.2) | (58.3) | (43.2) | (50.0) | (33.3) | (49.0) | (46.7) |
| rs3817198 - TC | 25 | 64 | 10 | 79 | 6 | 83 | 13 | 48 | 24 | 4 | 61 | 28 |
| N (%) | (37.9) | (46.4) | (50.0) | (42.9) | (22.2) | (46.9) | (36.1) | (50.5) | (36.4) | (66.7) | (42.7) | (46.7) |
| rs3817198 - CC | 10 | 7 | 4 | 13 | 3 | 14 | 2 | 6 | 9 | 0 | 12 | 4 |
| N (%) | (15.2) | (5.1) | (20.0) | (7.1) | (11.1) | (7.9) | (5.6) | (6.3) | (13.6) | (0.0) | (8.4) | (6.6) |
| Total N (%) | 66 | 138 | 20 | 184 | 27 | 177 | 36 | 95 | 66 | 6 | 143 | 60 |
| (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | (100) | |
| P value a | 0.223 | 0.029 | 0.166 | 0.275 | 0.954 | |||||||
Values in bold indicate statistical significance (p < 0.05)
aChi-square