Table 3.
Correlation between the genotype frequencies of the polymorphisms and the hormone receptors (overall)
| Estrogen | Progesterone | Her-2 | |||||
|---|---|---|---|---|---|---|---|
| Polymorphisms | Negative | Positive | Negative | Positive | Negative | Positive | Inconclusive |
| rs3803662 - TT N (%) | 13 (16.5) | 20 (18.0) | 16 (18.0) | 17 (16.5) | 23 (16.9) | 7 (14.9) | 3 (100.0) |
| rs3803662 - TC N (%) | 33 (41.8) | 56 (50.5) | 51 (41.8) | 38 (42,7) | 66 (48.5) | 21 (44.7) | 0 (0.0) |
| rs3803662 – CC N (%) | 33 (41.8) | 35 (31.5) | 46 (37.7) | 35 (39.3) | 47 (34.6) | 19 (40.4) | 0 (0.0) |
| Total | 79 (100.0) | 111 (100.0) | 122 (100.0) | 89 (100.0) | 136 (100.0) | 47 (100.0) | 3 (100.0) |
| P value a | 0.257 | 0.504 | 0.469 | ||||
| rs2981582 – TT N (%) | 15 (219.2) | 31 (27.2) | 16 (18.0) | 30 (28.6) | 33 (23.9) | 21 (25.5) | 1 (33.4) |
| rs2981582 – TC | 38 (48.7) | 60 (52.6) | 47 (52.8) | 52 (49.5) | 65 (47.1) | 28 (59.6) | 2 (66.6) |
| N (%) | |||||||
| rs2981582 – CC | 25 (32.1) | 23 (20.2) | 26 (29.2) | 23 (21.9) | 40 (29.0) | 7 (14.9) | 0 (0.0) |
| N (%) | |||||||
| Total | 78 (100.0) | 114 (100.0) | 89 (100.0) | 105 (100.0) | 138 (100.0) | 47 (100.0) | 3 (100.0) |
| P value a | 0.054 | 0.076 | 0.120 | ||||
| rs13281615 - AA N (%) | 20 (25.3) | 30 (26.3) | 26 (28.9) | 25 (23.8) | 32 (23.2) | 14 (29.2) | 2 (66.6) |
| rs13281615 - AG N (%) | 35 (44.3) | 56 (49.1) | 40 (44.4) | 51 (48.6) | 68 (49.3) | 20 (41.7) | 1 (33.4) |
| rs13281615 - GG N (%) | 24 (30.4) | 28 (24.6) | 24 (26.7) | 29 (27.6) | 38 (27.5) | 14 (29.2) | 0 (0.0) |
| Total | 79 (100.0) | 114 (100.0) | 90 (100.0) | 105 (100.0) | 138 (100.0) | 48 (100.0) | 3 (100.0) |
| P valuea | 0.523 | 0.566 | 0.291 | ||||
| rs889312 - CC N (%) | 12 (15.2) | 15 (13.2) | 10 (11,1) | 17 (16.2) | 21 (15.2) | 5 (10.4) | 0 (0.0) |
| rs889312 - CA N (%) | 35 (44.3) | 54 (47.4) | 45 (50.0) | 45 (42.9) | 61 (44.2) | 25 (52.1) | 1 (33.3) |
| rs889312 - AA N (%) | 32 (40.5) | 45 (39.5) | 35 (38.9) | 43 (41.0) | 56 (40.6) | 18 (37.5) | 2 (66.7) |
| Total | 79 (100.0) | 114 (100.0) | 90 (100.0) | 105 (100.0) | 138 (100.0) | 48 (100.0) | 3 (100.0) |
| P value a | 0.921 | 0.760 | 0.554 | ||||
| rs3817198 - TT N (%) | 42 (53.8) | 51 (44.7) | 49 (55.1) | 45 (42,9) | 68 (49.3) | 21 (44.7) | 0 (0.0) |
| rs3817198 - TC N (%) | 31 (39,7) | 54 (47.4) | 34 (38.2) | 52 (49,5) | 59 (42.8) | 23 (48.9) | 3 (100) |
| rs3817198 - CC N (%) | 5 (6.4) | 9 (7.9) | 6 (6.7) | 8 (7.6) | 11 (8.0) | 3 (6.4) | 0 (0.0) |
| Total | 78 (100.0) | 114 (100.0) | 89 (100.0) | 105 (100.0) | 138 (100.0) | 47 (100.0) | 3 (100.0) |
| P value a | 0.248 | 0.145 | 0.449 | ||||
Values in bold indicate statistical significance (p < 0.05)
aChi-square