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. Author manuscript; available in PMC: 2016 Mar 24.
Published in final edited form as: Nature. 2015 Sep 16;525(7570):528–532. doi: 10.1038/nature15367

Extended Data Figure 4. Neutrophil homeostasis is altered in germ-free mice.

Extended Data Figure 4

a, Total WBC counts and numbers of leukocyte subsets in blood of specific pathogen free (SPF) and germ-free (GF) mice (n = 5 mice). b, Total BM cellularity and numbers of leukocyte subsets in the BM of SPF and GF mice (SPF: n = 5 mice; GF: n = 4 mice). c, Total spleen cellularity and numbers of leukocyte subsets in the spleen of SPF and GF mice (SPF: n = 5 mice; GF: n = 4 mice). d, Copy numbers of 16S ribosomal DNA in feces from SPF mice, GF mice, GF mice reconstituted by fecal transplantation (GF-FT), and antibiotics-treated GF mice (GF-ABX; n = 5,5,5,4 mice). e, Numbers of total circulating neutrophils in SPF, GF, GF-FT, and GF-ABX mice (n = 5,5,5,3 mice). Error bars, mean ± s.e.m. * P < 0.05, ** P < 0.01, *** P < 0.001, data representing ≥2 independent experiments analysed with unpaired Student’s t-test.