FIGURE 4.
Schematic diagrams of the human 28S (A) and 18S (B) rRNA secondary structures showing locations of nucleotides with changed accessibility to chemical probes. Here and thereafter, 28S rRNA and 18S rRNA helices are designated with uppercase (H) and lowercase (h) letters, respectively. Arrows directed to and from nucleotides designate protections and enhancements, respectively. In A, nucleotides identified after treatment with hydroxyl radicals are shown in violet (complexes 6–8), black (6 and 7), green (4 and 6–8), and blue (4 and 8) and after treatment with benzoyl cyanide in orange (6–8), olive (7), and magenta (4 and 6–8). In B, benzoyl cyanide enhancements and protections are shown in black.