Table 4.
Items of concern regarding HIV vaccine trial participation and willingness to participate in a future triala
| Items of Concern Regarding Vaccine Trial Participation | Enrollment (N=799) | 18 Months (N=737) |
|---|---|---|
| Short-term side effects from the injection, such as fever, aches and pains, and pain or infection at the injection site | ||
| Very concerned | 122 (15.3%) | 93 (12.6%) |
| Somewhat concerned | 251 (31.4%) | 208 (28.2%) |
| Not concerned at all | 426 (53.3%) | 436 (59.2%) |
| Long-term side effects | ||
| Very concerned | 332 (41.6%) | 339 (46.0%) |
| Somewhat concerned | 229 (28.7%) | 222 (30.1%) |
| Not concerned at all | 238 (29.8%) | 176 (23.9%) |
| Having multiple HIV tests during the study | ||
| Very concerned | 58 (7.3%) | 32 (4.3%) |
| Somewhat concerned | 87 (10.9%) | 71 (9.6%) |
| Not concerned at all | 652 (81.8%) | 634 (86.0%) |
| Missing | 2 | 0 |
| Testing positive on standard HIV test because of receipt of the vaccine | ||
| Very concerned | 382 (47.8%) | 415 (56.3%) |
| Somewhat concerned | 219 (27.4%) | 193 (26.2%) |
| Not concerned at all | 198 (24.8%) | 129 (17.5%) |
| Spouse/Partner not wanting to have sexual relations | ||
| Very concerned | 220 (27.5%) | 189 (25.6%) |
| Somewhat concerned | 196 (24.5%) | 184 (25.0%) |
| Not concerned at all | 383 (47.9%) | 364 (49.4%) |
| Spouse/partner feels you are protected against HIV and insists on intercourse without a condom | ||
| Very concerned | 208 (26.0%) | 171 (23.2%) |
| Somewhat concerned | 297 (37.2%) | 241 (32.7%) |
| Not concerned at all | 294 (36.8%) | 325 (44.1%) |
| Other Negative reactions of family/friends | ||
| Very concerned | 172 (21.5%) | 146 (19.9%) |
| Somewhat concerned | 177 (22.2%) | 148 (20.1%) |
| Not concerned at all | 449 (56.3%) | 441 (60.0%) |
| Missing | 1 | 2 |
| Not being able to donate/sell blood while in the study | ||
| Very concerned | 116 (14.5%) | 128 (17.4%) |
| Somewhat concerned | 124 (15.5%) | 111 (15.1%) |
| Not concerned at all | 558 (69.9%) | 498 (67.6%) |
| Missing | 1 | 0 |
| Job discrimination | ||
| Very concerned | 214 (26.8%) | 200 (27.1%) |
| Somewhat concerned | 162 (20.3%) | 140 (19.0%) |
| Not concerned at all | 422 (52.9%) | 396 (53.8%) |
| Missing | 1 | 1 |
| Permanent injury or death | ||
| Very concerned | 562 (70.4%) | 584 (79.2%) |
| Somewhat concerned | 72 (9.0%) | 79 (10.7%) |
| Not concerned at all | 164 (20.5%) | 74 (10.0%) |
| Missing | 1 | |
| Avoiding pregnancy during the study | ||
| Very concerned | 81 (10.1%) | 80 (10.9%) |
| Somewhat concerned | 57 (7.1%) | 58 (7.9%) |
| Not concerned at all | 661 (82.7%) | 599 (81.3%) |
| Willingness to participate in an HIV vaccine trial | ||
| definitely willing | 461 (57.7%) | 288 (39.1%) |
| probably willing | 249 (31.2%) | 338 (45.9%) |
| probably not willing | 45 (5.6%) | 70 (9.5%) |
| definitely not willing | 44 (5.5%) | 41 (5.6%) |
a
Site staff administered a questionnnaire that asked women, “if you were thinking of joining an HIV vaccine study, how concerned would you be about the following?” Specific items of concern are listed in the table in the same order as the questionnaire.