Table 1.
Baseline characteristics of HIV-infected and HIV-uninfected participants
| HIV-infected (n=182) |
HIV-uninfected (n=267) |
p-value* | |
|---|---|---|---|
| Age (years) | 50.2(47.5–54.7) | 48.4(44.5–53.1) | <0.001 |
| Race (%) | 0.429 | ||
| White | 81.9 | 85 | |
| Black | 14.8 | 10.9 | |
| Hispanic | 3.3 | 4.1 | |
| Center (%) | 0.057 | ||
| Baltimore/ Washington DC | 32.4 | 26.2 | |
| Chicago | 19.8 | 20.6 | |
| Pittsburgh | 19.8 | 15.7 | |
| UCLA | 28 | 37.5 | |
| Smoking Status (%) | 0.004 | ||
| Current | 31.3 | 19.5 | |
| Past | 47.8 | 48.3 | |
| Never | 20.9 | 32.2 | |
| BMI (%) | 0.001 | ||
| <20 kg/m2 | 6.6 | 1.9 | |
| 20 – 24.9 kg/m2 | 50.5 | 39.3 | |
| 25 – 29.9 kg/m2 | 33 | 39.7 | |
| ≥ 30 kg/m2 | 9.9 | 19.1 | |
| HCV infection (%) | 9.9 | 3.7 | 0.008 |
| History of diabetes** (%) | 8.8 | 5.2 | 0.139 |
| Depressive Symptoms*** (%) | 25.3 | 19.5 | 0.152 |
| Self-reported hypertension or medication (%) | 22.5 | 20.8 | 0.654 |
| Self-reported diabetes or medication (%) | 6 | 3 | 0.119 |
| Kidney disease (%) | 2.7 | 0.4 | 0.032 |
| Liver disease (%) | 2.7 | 0 | 0.006 |
| Cancer (%) | 3.3 | 0.7 | 0.045 |
| Total number of comorbidities | 0(0–1) | 0(0–1) | 0.081 |
| Morning blood draw (%) | 61.5 | 66.7 | 0.265 |
| Free testosterone (FT, ng/dL) | 63.8(51.4–79.9) | 70.6(58.6–86.5) | 0.001 |
| Number of FT measurements contributed | 4(3–5) | 4(3–5) | 0.141 |
| Years from first FT to last FT measurements | 5.6(2.8–9.5) | 6.7(3–9.4) | 0.150 |
| HIV-infected participants | |||
| Nadir CD4 count (cells/mm3) | 223(149–337) | - | |
| Current CD4 count (cells/mm3) | 371(236–528) | - | |
| HIV RNA <400 copies/ml (%) | 65.2 | - | |
| ART before HAART (%) | 57.7 | - | |
| HAART in last 6 months (%) | 98.9 | - | |
| PI-based regimen (%) | 59.9 | - | |
| NNRTI-based regimen (%) | 36.8 | - | |
| Cumulative years on HAART | 0.29(0.12–0.47) | - | |
| History of AIDS (%) | 9.3 | - |
Data are reported as median (interquartile range) or percentage.
*
By the non-parametric Wilcoxon test or Chi-square or Fisher exact test, as appropriate.
HCV defined by positive antibodies or HCV-RNA Yes/No
**
History of DM (DM: Fasting glucose≥ 126 mg/dl or self-reported DM and use of DM medications