Table 3.
Genotoxic response for lacZ mutagenicity results in glandular stomach (GS), small intestine (SI), liver, (Lv), lung (Lg), and bone marrow (BM), and micronucleus (MN) results in reticulocytes (RETs) and normochromatic erythrocytes (NCEs). Sensitivity for each tissue is also presented.
| Compound |
lacZ |
MN |
|||||
|---|---|---|---|---|---|---|---|
| GS | SI | Lv | Lg | BM | RETs | NCEs | |
| BaP | +++ | +++ | +++ | +++ | +++ | + | ++ |
| BaA | + | + | WP | − | + | − | − |
| DBahA | + | +++ | + | +++ | − | + | + |
| BbF | +++ | +++ | +++ | ++ | ++ | + | + |
| CHRY | − | + | − | WP | − | − | − |
| BkF | + | ++ | + | + | + | + | + |
| INDENO | + | +++ | + | + | + | − | − |
| BghiP | − | + | − | + | − | − | − |
| DBalP | ++ | + | ++ | + | +++ | ++ | + |
| Total Pos | 7 | 9 | 7 | 8 | 6 | 5 | 5 |
| Total Neg | 2 | 0 | 2 | 1 | 3 | 4 | 4 |
| Sensitivity | 78% | 100% | 78% | 89% | 67% | 56% | 56% |
+: Dose–response, 1.5–5-fold above background; ++: Dose–response, 5–10-fold above background; +++: Dose–response, > 10-fold above background; WP (weak positive): dose–response, but below 1.5-fold above background; −: Negative.