Table 2. Hazard ratios for cardiovascular disease in psoriasis patients with sleep disorders, as compared with psoriasis patients without sleep disorders.

	Crude HR	(95% CI)	P-value	Adjusted HR* (ATE)	(95% CI)	P-value
Ischemic heart disease or acute stroke	1.77	(1.60–1.95)	<0.001	1.38	(1.34–1.41)	<0.001
Ischemic heart disease	1.77	(1.59–1.96)	<0.001	1.25	(1.22–1.28)	<0.001
Stroke	1.74	(1.34–2.25)	<0.001	1.24	(1.16–1.33)	<0.001

Abbreviations: ATE: average treatment effect; HR: hazard ratio; CI: confidence interval; CVD: cardiovascular disease

*Adjusted for sex, age category, comorbidities within 1 year before index date (hypertension, diabetes, hyperlipidemia, obesity, depression, bipolar disorder, anxiety, alcoholism), psychiatric disorders within 6 months after the index date (depression, bipolar disorder, anxiety, alcoholism) and propensity score weighting.