Table 1.
Clinical data for enrolled patients
| Variables | Total patients with AD
|
Patients with ApoE4
|
Patients without ApoE4
|
P-value |
|---|---|---|---|---|
| (n=22) | (n=7) | (n=15) | ||
| Sex, male/female | 12/10 | 4/3 | 8/7 | NS |
| Age (years) | 63.9±8.5 (48–83) | 63.6±4.0 (58–68) | 64.1±10.2 (48–83) | NS |
| Age at onset (years) | 58.7±8.7 (46–79) | 58.4±4.0 (54–63) | 58.8±10.4 (46–79) | NS |
| Duration of illness (years) | 5.2±2.1 (1–9) | 5.1±0.9 (4–7) | 5.3±2.4 (1–9) | NS |
| DUD (years) | 1.9±1.6 (0–6) | 1.4±1.0 (0–3) | 2.3±1.7 (0–6) | NS |
| ADAS | 22.4±13.2 (6.3–55.0) | 22.7±14.4 (9.3–53.0) | 23.1±13.3 (6.3–55.0) | NS |
| MMSE | 18.1±5.1 (10–25) | 19.1±6.0 (10–24) | 17.8±4.9 (11–25) | NS |
Notes: Data are means ± standard deviation (range). Differences in sex distribution were analyzed using χ2 test. Differences in other clinical valuables were compared with Mann–Whitney U-test.
Abbreviations: AD, Alzheimer’s disease; DUD, duration of untreated dementia; ADAS, Alzheimer’s Disease Assessment Scale; MMSE, Mini-Mental State Examination; NS, not significant.