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. 2016 Jan 8;9:231–241. doi: 10.2147/OTT.S96710

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© 2016 Ge et al. This work is published and licensed by Dove Medical Press Limited

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dsP53-285 inhibits PCa cells mainly by upregulating p21 expression.

Notes: LNCaP and DU145 cells were transfected with the indicated dsRNAs at 50 nM for 72 hours. (A) Cell cycle distribution was evaluated by using flow cytometry with PI staining. (B) The cell proliferation ability was assessed by the CellTiter 96^® AQ_ueous One Solution Cell Proliferation Assay kit. OD values served as the detection index. *P<0.05 and **P<0.01 compared with the dsP53-285 group. (C) Representative photographs of colony formation assay. (D) Quantification of the cell colony formation. ^#P<0.05 compared with the dsP53-285 group.

Abbreviations: PCa, prostate cancer; dsRNA, double-stranded RNA; PI, propidium iodide; OD, optical density.