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. 2016 Jan 8;11:179–201. doi: 10.2147/IJN.S97286

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© 2016 Archibald et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Morphologies and viability of PC3 and LNCaP tumor spheroids after 15 days of treatment with free or micellar sorafenib 2.5 μM and/or nilotinib 3 μM.

Notes: Representative photographs of PC3 (A) and LNCaP (C) tumor spheroids were taken following treatment as indicated. Tumor spheroid viability was measured by the activity of acid phosphatase of PC3 (B) and LNCaP (D) tumor spheroids. ^*P<0.05 compared to control, ^**P<0.05 comparing free drug versus micellar treatments, and ^***P<0.05 comparing of free drug versus combination treatments. Scale bar denotes 100 μm.

Abbreviation: SMA, poly(styrene-co-maleic) acid.