Table 1.

Previous reports of L-asparaginase (L-asp) hypersensitivity reactions in dogs and cats

Reference	Number and species	Protocol	Type and route	Dose	Number of L-asp prescribed	Number and type of HSR	Percent reaction
20	1 dog	Adria/DTIC, L-asp, vaccine	Native IP	20 000 IU/m2	3	1 total: death	Case report
10	62 dogs	L-asp maintenance	PEG IM vs native IP	400 IU/kg BW	Until relapse	12 total: all native IP; 9 shock, 3 angioedema	19.3%
15	69 dogs	L-asp maintenance	PEG IM vs native IM	400 IU/kg BW	Until relapse	3 total: 1 PEG: urticaria, 2 native: 1 limb edema & 1 shock, seizures	4.3%
16	68 dogs	ACOPA ll	Native IM	10 000 IU/m2 Max 10 000 IU	4	4 total: 3 collapse, 1 angioedema	5.8%
17	98 dogs	VELCAP-L	Native IM	10 000 IU/m2	5	5 total	5.1%
18	82 dogs	VELCAP-S	Native IM	10 000 IU/m2 Max 10 000 IU	5	6 total	7.3%
19	93 dogs	VELCAP-SC	Native SQ	10 000 IU/m2 Max 10 000 IU	2	4 total	4.3%
8	48 dogs	Lomustine, L-asp, pred rescue	Native IM or SQ	400 IU/kg BW	Until relapse	5 total: all SQ; 3 grade l, 2 grade 2, vomiting, facial swelling, urticaria	10.4%
6	66 dogs	L-CHOP +/− CCNU, MOPP	Native SQ	400 IU/kg BW	2	2 total	3.0%
9	36 cats	L-asp rescue	Native IV, then IP	400 IU/kg BW	Until relapse	1 total	2.7%

BW — body weight.