Table 3.

Summary data for 6 dogs experiencing an HSR to L-asparaginase

Dog	Signalment	LSAa grade	Concurrent chemotherapy	Dose (IM, per kg BW)	L-asp number @ reaction	L-asp number post HSR	Clinical signs	VCOG grade
1	6.5 y FS Shar Pei	High	L-asp/CCNU	295 IU	3	6	Pruritus, anxiety, trembling	2
2	7 y MC Mixed	Intermedb to high	L-asp/CCNU	400 IU	2	0	Head-shaking, vomiting, diarrhea, fever, tachycardia	3
3	6 y FS Mixed	Intermed	CHOP	400 IU	1	0	Skin rash	2
4	6.5 y FS Pit bull	Intermed	L-asp/CCNU rescue	385 IU	2	0	Ptyalism, lethargy, generalized erythema, urticaria, hypotension. Recurrent urticaria required repeat therapy	4
5	6.5 y FS Mixed	High	L-asp/CCNU rescue	400 IU	2	0	Kyphosis, lethargy, anorexia, vomiting, colitis, tachycardia, urticaria, facial edema, swollen paws. Recurrent urticaria and vomiting required repeat therapy	4
6	7 y MC Airedale	High	L-asp/CCNU	400 IU	3	0	Vomiting, lethargy, tachycardia, hypotension	4

^aLSA — Lymphoma.

^bIntermed — Intermediate.

BW — body weight.

Dog 1 Treatment: IM and PO diphenhydramine (PO diphenhydramine continued, PO prednisone prescribed at the 7th dose and continued).

Dog 2 Treatment: IV fluids; IM dexamethasone and diphenhydramine; SQ metaclopromide; PO famotidine and sucralfate.

Dog 3 Treatment: One dose PO diphenhydramine.

Dog 4 Treatment: IV fluids, epinephrine, dexamethasone, and ondansetron; IM diphenhydramine; PO diphenhydramine and prednisone.

Dog 5 Treatment: IV epinephrine, dexamethasone, and ondansetron; IM diphenhydramine; PO prednisone and diphenhydramine.

Dog 6 Treatment: IV fluids, dexamethasone, ondansetron, and famotidine; IM diphenhydramine; SQ epinephrine and maropitant.