Table 4.

Number of L-asparaginase doses prior to developing an HSR

Number of doses	Number of HSRs (% affected)	Reference	Number of treated dogs	Number of HSRs in the current study
1	1 (1%)	17	98	1 (0.7%)
2	7 (2.8%)	18	82	3 (2.1%)
		17	98
		6	66
3	1 (1%)	17	98	1 (0.7%)
4	3 (1.7%)	17	98	1 (0.7%)
		18	82
5	1 (1.2%)	18	82	0

Another publication reported 5 HSRs to L-asparaginase that occurred within 24 h of receiving a median of 3 doses (range: 2 to 6) (8). All dogs in that study were pretreated with diphenhydramine and were on oral prednisone (8).