Table 4.
Expression of TH, NET, and VMATs in tumor samples (0=less than 10% of tumor cells positive; 1+=10–25% positive cells; 2+=25–50% positive cells, presented as moderate staining; 3+=50–75% positive cells, moderate to strong staining; and 4+=more than 75% of tumor cells positive, strong staining)
| Location | TH | NET | VMAT1 | VMAT2 | [18F]-DA | [18F]-DOPA (SUVmax) |
|---|---|---|---|---|---|---|
| Adrenal 1 | 4+ | 2+ | 1+ | 4+ | 2.15 | 6.46 |
| Adrenal 2 | 4+ | 3+ | 1+ | 3+ | 1.98 | 5.79 |
| Bone | 4+ | 2+ | 0 | 0 | — | 1.42 |
| Liver 1 | 3+ | 1+ | 0 | 3+ | 2.46 | 3.31 |
| Liver 2 | 4+ | 3+ | 1+ | 4+ | 1.89 | 2.79 |
| Liver 3 | 2+ | 0 | 0 | 0 | — | 3.24 |
| Lung | 2+ | 4+ | 0 | 3+ | — | 1.15 |
| Ovary | 4+ | 2+ | 1+ | 2+ | 1.92 | 3.05 |
| s.c. 1 | 4+ | 2+ | 0 | 2+ | — | 1.88 |
| s.c. 2 | 3+ | 3+ | 0 | 3+ | — | 2.25 |
| s.c. 3 | 4+ | 4+ | 0 | 2+ | — | 2.09 |
[18F]-DA and [18F]-DOPA PET uptake in organ metastatic and s.c. tumors expressed in SUVmax; calculated from images after 60–70 min after administration. Numbers 1–3 indicate number of samples. A dash sign “—” presents SUVmax values less than 0.3 for both [18F]-DA and [18F]-DOPA.