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. Author manuscript; available in PMC: 2016 Apr 22.
Published in final edited form as: Nature. 2015 Oct 5;526(7574):578–582. doi: 10.1038/nature14984

ED 8. Hh signaling mediates both mesenchymal and epithelial quiescence during homeostasis and injury repair in the lung.

ED 8

The lung epithelium actively maintains mesenchymal quiescence through paracrine Hh signaling, which also regulates a feedback loop to maintain epithelial quiescence. Epithelial injury leads to down-regulation of Hh signaling and loss of mesenchymal quiescence, which in turn stimulates epithelial regeneration to replete the airway epithelium until homeostasis is re-established.