Table 5. Association of FUT2 and FUT3 polymorphisms with clinical characteristics of UC patients.
| Genotype/Allele | Distal colitis(n = 311)(%) | Extensive colitis(n = 174)(%) | OR(95%CI) | P |
|---|---|---|---|---|
| FUT2 rs281377 | ||||
| TT | 231(74.3) | 125(71.8) | ||
| TC+CC | 80(25.7) | 49(28.2) | 0.746(1.132–1.717) | 0.560 |
| T allele | 532(85.5) | 294(84.5) | ||
| C allele | 90(14.5) | 54(15.5) | 0.753(1.086–1.566) | 0.660 |
| FUT2 rs1047781 | ||||
| AA | 90(28.9) | 65(37.4) | ||
| AT+TT | 221(71.1) | 109(62.6) | 0.461(0.683–1.012) | 0.057 |
| A allele | 346(55.6) | 211(60.6) | ||
| T allele | 276(44.4) | 137(39.4) | 0.623(0.814–1.063) | 0.131 |
| FUT2 rs601338 | ||||
| GG | 308(99.0) | 171(98.3) | ||
| GA+AA | 3(1.0) | 3(1.7) | 0.360(1.801–9.022) | 0.468 |
| G allele | 619(99.5) | 345(99.1) | ||
| A allele | 3(0.5) | 3(0.9) | 0.360(1.794–8.938) | 0.469 |
| FUT3 rs28362459 | ||||
| TT | 162(52.1) | 119(68.4) | ||
| TG+GG | 149(47.9) | 55(31.6) | 0.340(0.503–0.742) | 0.000 |
| T allele | 450(72.3) | 286(82.2) | ||
| G allele | 172(27.7) | 62(17.8) | 0.409(0.567–0.786) | 0.001 |
| FUT3 rs3745635 | ||||
| GG | 202(65.0) | 134(77.0) | ||
| GA+AA | 109(35.0) | 40(23.0) | 0.362(0.553–0.845) | 0.006 |
| G allele | 502(80.7) | 303(87.1) | ||
| A allele | 120(19.3) | 45(12.9) | 0.429(0.621–0.900) | 0.011 |
| FUT3 rs3894326 | ||||
| TT | 253(81.4) | 153(87.9) | ||
| TA+AA | 58(18.6) | 21(12.1) | 0.350(0.599–1.025) | 0.060 |
| T allele | 562(90.4) | 326(93.7) | ||
| A allele | 60(9.6) | 22(6.3) | 0.381(0.632–1.050) | 0.074 |
The covariants also included sex, age of onset, smoking, severity of the disease. Nevertheless, these covariants did not affect the allelic and genotypic distributions of FUT2 and FUT3 in UC patients and the controls.