Table 1.
Substrates and Inhibitors of BCRP/Bcrp.
| Substrates | References |
|---|---|
| Carcinogens | |
| Aflatoxin B1 | [55] |
| 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) | [56] |
| Chemotherapy drugs | |
| Etoposide | [57] |
| Imatinib | [58] |
| Mitoxantrone | [46–48] |
| Methotrexate | [59] |
| Topotecan | [60] |
| SN-38 | [61] |
| Endogenous compounds | |
| Estrone-3-sulfate | [62] |
| Folic acid | [63] |
| Protoporphyrin IX | [64] |
| Uric acid | [65] |
| Flavonoids | |
| Biochanin A-glucuronide | [66] |
| Biochanin A-sulfate | [67] |
| Daidzein | [68, 69] |
| Daidzein-sulfate | [70] |
| Genistein | [69, 71] |
| Genistein-glucuronide | [70, 72, 73] |
| Genistein-sulfate | [70, 72, 73] |
| Quercetin | [74] |
| Fluorescent dyes | |
| BODIPY-Prazosin | [75] |
| Hoechst 33342 | [76] |
| Pheophorbide a | [60, 77] |
| Rhodamine 123 | [75] |
| Other pharmaceutical drugs | |
| Cimetidine | [56] |
| Ciprofloxacin | [78] |
| Danofloxacin | [79] |
| Enrofloxacin | [80] |
| Glyburide | [81] |
| Nitrofurantoin | [82] |
| Prazosin | [83] |
| Inhibitors | |
| Chemotherapy drugs | |
| Gefitinib | [84] |
| Imatinib | [85] |
| Fungal toxins | |
| FTC | [48] |
| Ko143 | [86] |
| Flavonoids | |
| Biochanin A | [87, 88] |
| Daidzein | [87, 89] |
| Formonetin | [90] |
| Genistein | [87, 89, 90] |
| Glycitein | [90] |
| Endogenous compounds | |
| 17β-estradiol | [91] |
| Estrone | [91] |
| Pharmaceutical drugs | |
| Cyclosporin A | [92] |
| Omeprazole | [93] |
| Other | |
| GF120918 | [94] |