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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Stem Cells. 2015 Oct 5;33(12):3635–3642. doi: 10.1002/stem.2208

Figure 4. Impact of normal hematopoietic cell dose on cycling of leukemia cells at time of disease progression.

Figure 4

At the time of euthanasia due to a pre-morbid state, the cycling status of marrow leukemic cells was measured. The % of GFP+ leukemic cells that expressed Ki67 is shown. (A) Representative Ki67 staining of the GFP+ leukemic cells. (B) Comparison of % Ki67+ tumor cells at different LSK doses at the time of euthanasia. A dose of 50,000 purified LSKs resulted in a significantly increased fraction of Ki67+ leukemic cells, compared to groups transplanted with lower doses of purified LSKs (p=0.0075).