Table 2.
Characteristics of invasive breast tumors (stage, lymph node involvement, tumor size, estrogen receptor (ER), progesterone receptor (PR) and HER2 status), by periodontal disease status, Women’s Health Initiative Observational Study
| Periodontal Disease | ||||
|---|---|---|---|---|
| Total 2,124 |
Yes 616 |
No 1,508 |
p-value* | |
| Stage | ||||
| Localized | 1,590 | 454 (75.3) | 1,136 (76.7) | 0.51 |
| Regional or distant | 495 | 149 (24.7) | 346 (23.3) | |
| Missing | 39 | 13 | 26 | |
|
| ||||
| Nodal status | ||||
| Negative | 1,445 | 418 (75.2) | 1,027 (76.5) | 0.53 |
| Positive | 453 | 138 (24.8) | 315 (23.5) | |
| Missing | 226 | 60 | 166 | |
|
| ||||
| Tumor size | ||||
| <2 cm | 1,431 | 414 (71.6) | 1,017 (71.8) | 0.54 |
| 2–4.9 cm | 498 | 141 (24.4) | 357 (25.2) | |
| >=5 cm | 66 | 23 (4.0) | 43 (3.0) | |
| Missing | 129 | 38 | 91 | |
|
| ||||
| ER/PR status | ||||
| ER+PR+ | 1,391 | 405 (70.9) | 986 (69.7) | 0.67 |
| ER+PR− | 290 | 87 (15.2) | 203 (14.3) | |
| ER-PR+ | 17 | 4 (0.7) | 13 (0.9) | |
| ER-PR− | 288 | 75 (13.1) | 213 (15.1) | |
| Missing | 138 | 45 | 93 | |
|
| ||||
| ER status | ||||
| Positive | 1,704 | 496 (86.0) | 1,208 (84.1) | 0.28 |
| Negative | 310 | 81 (14.0) | 229 (15.9) | |
| Missing | 110 | 39 | 71 | |
|
| ||||
| PR status | ||||
| Positive | 1,408 | 409 (71.4) | 999 (70.6) | 0.71 |
| Negative | 581 | 164 (28.6) | 417 (29.4) | |
| Missing | 135 | 43 | 92 | |
|
| ||||
| HER2 status | ||||
| Positive | 265 | 74 (13.8) | 191 (14.6) | 0.64 |
| Negative | 1,579 | 463 (86.2) | 1,116 (85.4) | |
| Missing | 280 | 79 | 201 | |
*
p-value, Chi-square test.