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Lck-cre transgenic (NZB × NZW)F1 males develop high levels of autoantibodies earlier than non-transgenic males. Production of anti-dsDNA IgG (a), anti-dsDNA IgM (b) and anti-chromatin IgG (c) at 6 months in male (NZB × NZW)F1 experimental mice were measured. Total IgG and IgM (d) production at 2 months and 4 months is also shown. N=30 mice per genotype (*, p<0.05; **, p<0.01).
