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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Cell Biol Int. 2015 Oct 6;40(2):131–142. doi: 10.1002/cbin.10544

Figure 3. S. frutescens extract (SLE) suppressed the Gli/Hh signaling in Shh Light II and TRAMP-C2QGli cells.

Figure 3

A: Cyclopamine (Cyc) inhibited Gli-reporter activity in Shh Light II cells that were stimulated by conditioned medium (CM) or SAG. B: In the presence of CM, SLE significantly blocked Gli-reporter activity. C: In the presence of SAG, SLE significantly inhibited Gli-reporter activity. D: SLE but not cyclopamine inhibited the basal Gli-reporter activity in Shh Light II cells. E: SLE significantly inhibited the basal Gli-reporter activity in a dose-dependent manner in TRAMP-C2QGli cells. Each experiment was conducted at least thrice in triplicate. Error bars indicate standard deviation (SD). * P<0.05, ** P<0.01, *** P<0.001.