Table 2. Most significantly associated SNPs.

SNP	Minor allele	MAF	OR	95% CI	P-value
Discoverya
rs7661530	T	0.33	1.27	(1.17–1.39)	6.1 × 10−8
rs6838116	A	0.33	1.28	(1.17–1.40)	3.1 × 10−8
rs7675300	A	0.31	1.27	(1.16–1.39)	1.1 × 10−7
rs16870989	A	0.31	1.27	(1.16–1.39)	1.1 × 10−7
rs145489027	A	0.30	1.30	(1.19–1.42)	1.0 × 10−8
rs1495509	C	0.31	1.27	(1.17–1.39)	7.8 × 10−8
Replication
eMERGEb
rs7661530	T	0.35	1.24	(0.96–1.59)	0.09
rs7675300	A	0.33	1.32	(1.01–1.70)	0.04
rs16870989	A	0.33	1.28	(0.98–1.65)	0.06
rs145489027	A	0.32	1.28	(0.98–1.68)	0.07
rs1495509	C	0.33	1.28	(0.98–1.65)	0.06
GoDARTSc
rs7661530	T	0.37	1.05	(0.89–1.23)	0.84
rs6838116	A	0.37	1.08	(0.95–1.20)	0.57
rs16870989	A	0.34	1.15	(1.01–1.30)	0.03
rs145489027	A	0.33	1.12	(0.99–1.27)	0.08
rs1495509	C	0.34	1.15	(1.01–1.30)	0.03
Meta-analysis
rs7661530	T	—	1.22	(1.13–1.31)	9.6 × 10−8
rs6838116d	A	—	1.17	(1.10–1.24)	4.2 × 10−7
rs7675300d	A	—	1.27	(1.17–1.39)	1.4 × 10−8
rs16870989	A	—	1.23	(1.15–1.32)	4.9 × 10−9
rs145489027	A	—	1.24	(1.16–1.33)	2 × 10−9
rs1495509	C	—	1.23	(1.15–1.32)	1.9 × 10−9

Abbreviations: CI, confidence interval; eMERGE, Electronic Medical Records and Genomics; GoDARTS, Genetics of Diabetes Audit and Research in Tayside, Scotland; MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism.

^aFrom a multivariable logistic regression assuming an additive genetic model and adjusted for 10 principal components (PCs), birth year and sex.

^bFrom a multivariable logistic regression (157 cases and 769 controls) assuming an additive genetic model and adjusted for 3 PCs, birth year and sex.

^cFrom a meta-analysis (710 cases and 3,599 controls) adjusted for age and sex. The P-value for the Q-score P-value was >0.05 for each SNP.

^dBased on only two data sets.