Table 3. Association analyses by racial groups for SNP rs145489027.
| Racial group | Cases | Controls | MAF cases | MAF controls | OR | 95% CI | P-valuea |
|---|---|---|---|---|---|---|---|
| European ancestry | 1346 | 4661 | 0.37 | 0.32 | 1.3 | (1.2–1.4) | 2.5 × 10−7 |
| African ancestry | 178 | 701 | 0.13 | 0.10 | 1.2 | (0.9–1.8) | 0.24 |
| Otherb | 71 | 123 | 0.29 | 0.20 | 1.4 | (0.8–2.6) | 0.25 |
Abbreviations: CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism.
a
From a multivariable logistic regression assuming an additive genetic model and adjusting for 10 principal components, birth year and sex.
b
Includes subjects not meeting criteria for inclusion with African ancestry and European ancestry.