Figure 2. SC-435 prevents wasting and reduces biomarkers of hepatocellular injury and cholestasis in mdr2−/− mice.

Body weights were recorded for mice of the four groups during the 14 days of intervention (A). ALT, total bilirubin, and alkaline phosphatase levels were determined on blood sampled by cardiocentesis on DOT 14. Statistical analysis: unpaired t test was applied to the data from treated and control mdr2−/− mice in A, one-way ANOVA with Tukey’s multiple comparison test in B.