OSA-induced hypertension requires a high fat diet. A, Sham and OSA rats fed a normal chow diet had no difference in systolic blood pressures (n=4 per group). B, On high fat diet OSA rats exhibited significantly higher systolic blood pressure, as compared to sham rats, after 7 and 14 days of OSA (n=10-13 per group). C, OSA-induced hypertension was prevented by oral antibiotic treatment (n=6-9). HFD= high fat diet, Ab= antibiotic. Data are shown as the mean ± S.E.M., *p<0.05 for sham vs. OSA.