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Thrombin generation and inhibition pathways. (a) Thrombin (IIa) generation via the extrinsic, intrinsic, and common pathways. (b) Thrombin inhibition via tissue factor pathway inhibitor (TFPI), antithrombin III, and activated protein C (APC). (c) Heparin catalyzes thrombin inhibition by potentiating the activity of ATIII.
