Skip to main content
. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Ann Biomed Eng. 2015 Jul 14;44(4):1072–1084. doi: 10.1007/s10439-015-1377-5

FIGURE 3.

FIGURE 3

The effect of tissue factor surface density on peak thrombin concentration at the TF/TM interface. Maximum thrombin concentrations (nM) at the TF/TM interface were measured under varying TF surface densities under (a) venous (50 s−1) and (b) arterial (500 s−1) shear rates. TM levels were held constant at 1000 fmol/cm2. A thrombin concentration of 10 nM (dashed line) was used to indicate a surface threshold of bound TF that would lead to significant thrombin generation and platelet activation. This “cutoff level” occurs just beyond a TF surface density of 1.3 and 16 fmol/cm2 under venous and arterial shear rates, respectively.