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Subcellular localization of SMN function in motor neurons. The top image shows immunofluorescent staining of SMN protein throughout the cell body and processes of a primary rodent spinal motor neuron in culture. SMN has a number of different functions throughout the motor neuron cell body axon/neurites. Loss of SMN leads to perturbations in these cellular functions and therefore specific SMA phenotypes are associated with these subcellular functions.
