Table 4. Networks associated with the union of TB and NTM genes.
Molecules in Network | Score* | Focus Molecules | Top Diseases and Functions |
---|---|---|---|
CCL2, CCL5 CD14, CTSZ, CYBB, Fcer1, Fcgr2, Gm-csf, Gsk3, HLA-DQ, HLA-DR, lfn gamma, IFNGR1, IFNGR2, lge, IgG1, IL4, IL10, IL18, IL23, IL12 (complex), IL12B, lymphotoxin-alpha1-beta2, MHC Class II (complex), NOD2, NOS2, Nr1h, SCAVENGER receptor CLASS A, Sod, Tlr, TLR2, TLR4, TLR6, TNF, U1 snRNP | 33 | 17 | Cellular Function and Maintenance, Hematological System Development and Function, Infectious Disease |
26s Proteasome, BCR (complex), caspase, CD209, Cdk, Collagen type 1, Eotaxin, Fcgr3, HLA-DQB1, Hsp27, Iga, Ikb, IKBKG, IL1, IL6, IL12 (family), IL1B, IL1RN, Immunoglobulin, JK, LTA, MBL2, MICA, MMP1, N-cor, NFkB(complex), P2RX7, PTPN22, Ras homolog, SAA, TIRAP, TLR1, TLR9, VDR, Vegf | 33 | 16 | Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immunological Disease |
Bold: TB and NTM focus genes.
*Score: -log(Fisher’s Exact p-value)