Table 1. Morphological changes of the kidney and liver in DDC-fed mice.

		Control	Day 1		Day 3		Day 7
			0.1%	0.5%	0.1%	0.5%	0.1%	0.5%
Kidney	ATN score	0.0 ± 0.0	0.0 ± 0.0	0.2 ± 0.2	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.2 ± 0.2
Liver	Modified Ishak score
	Necrotic cells	0.2 ± 0.1	10 ± 0.3	16 ± 1.0*	8.8 ± 1.4	9.3 ± 0.8	2.0 ± 0.2	2.3 ± 0.6
	Portal inflammation	0.2 ± 0.2	1.0 ± 0.0	1.0 ± 0.0	1.0 ± 0.0	1.5 ± 0.2	2.3 ± 0.2	2.0 ± 0.0
	Interface hepatitis	0.0 ± 0.0	0.3 ± 0.2	0.5 ± 0.2	1.0 ± 0.0	1.3 ± 0.2	2.8 ± 0.2	3.7 ± 0.2
	Fibrosis	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	1.0 ± 0.0	1.0 ± 0.0

Acute tubular necrosis (ATN) scores and modified Ishak scores in control and 0.1% and 0.5% DDC-fed mice after 1, 3, and 7 days. Data are presented as mean ± SEM. DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine. *P < 0.05 compared with the 0.1% DDC-fed mice.