Table 2. IC50s for select antimalarials.
Values represent means and standard deviations for each assay run in four-replicates. For each parasite-line and each drug tested, p value is shown. ND = No Data.
| CQ | AT | LU | DHA | |
|---|---|---|---|---|
| mean±SD | mean±SD | mean±SD | mean±SD | |
| H 63 D 0 | 21.5±1.6 | 2.19±0.9 | 6.94±2.4 | 3.41±1.2 |
| H 63 D 10 | 8.6±2.5 | 3.42±1.9 | 4.48±0.6 | 1.87±0.2 |
| H 63 D 18 | 9.0±0.3 | 3.29±0.7 | 8.52±1.5 | 2.59±0.7 |
| H 63 D 30 | 16.1±2.3 | 2.61±1.3 | 10.92±0 | 1.72±0.3 |
| H 63 D 38 | 16.0±0.0 | 6.80±0.2 | 6.44±0.4 | 5.34±0.2 |
| H 63 D 44 | 48.5±0.0 | 9.06±0.7 | 5.10±0.4 | 1.43±0.9 |
| H 63 D 52 | 55.7±2.3 | 4.77±1.6 | 4.93±1.7 | 4.25±1.2 |
| H 63 D 65 | 39.9±0.0 | 8.01±3.2 | 5.43±0.2 | 1.41±0.0 |
| H 63 D 70 | 5.5±1.1 | 3.80±1.9 | 3.76±2.9 | 3.82±2.2 |
| H 63 D 78 | 15.2±0.2 | 9.18±1.0 | 31.21±0.1 | 3.08±0.5 |
| H 63 D 85 | 2.8±0.8 | 2.99±1.0 | 29.57±0.0 | 1.67±0.1 |
| H 63 D 90 | 49.8±1.8 | 10.77±0.2 | 19.70±0.1 | 1.10±0.1 |
| P = 0.0152 | P = 0.0005 | P = 0.0092 | P = 0.0002 | |
| H 74 D 0 | 5.80±0.0 | 5.96±0.7 | 27.96±0.6 | 7.59±0.0 |
| H 74 D 12 | 5.16±0.7 | 7.13±1.2 | 28.59±4.3 | 4.77±0.4 |
| H 74 D 19 | 11.43±3.2 | 5.46±1.6 | 26.41±0.5 | 1.29±0.4 |
| H 74 D 28 | 8.85±2.7 | 6.17±0.8 | 21.49±1.7 | 1.41±0.2 |
| H 74 D 35 | 8.14±2.0 | 5.88±0.3 | 17.68±1.9 | 3.53±1.1 |
| H 74 D 44 | 7.23±0.0 | 3.94±0.6 | 15.28±0.0 | 2.33±0.0 |
| H 74 D 52 | 9.73±0.9 | 1.79±0.8 | 25.18±2.0 | 12.28±0.8 |
| H 74 D 60 | 8.48±0.7 | 2.09±0.2 | 24.32±3.0 | 13.43±2.3 |
| H 74 D 68 | 7.60±1.4 | 2.42±0.2 | 21.56±1.6 | 13.92±2.2 |
| H 74 D 76 | 9.20±0.8 | 2.54±0.4 | 34.19±2.9 | 14.60±2.5 |
| P = 0.0475 | P = 0.0007 | P = 0.0035 | P = 0.0019 |