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. 2016 Jan 11;11(1):e0145831. doi: 10.1371/journal.pone.0145831

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© 2016 Mallela et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — A. Pathways of sphingolipid biosynthesis and degradation in yeast. Gene names are in italics, for enzymes requiring complex formation, genes are underlain in grey. B. Cladogram of ceramide synthases and their TLC domain containing paralogs of yeast (orange) and humans (blue). C. Alignment of LAG1, LAC1, YJR116w and YPR114w. The TLC domain is shown in red, the TRAM domain in blue. D. Homologues of LAG1, LAC1, YJR116w and YPR114w in intensively studied fungal species were found using PSI-Blasts (http://blast.ncbi.nlm.nih.gov/) as described in Table A in S1 File. The cladogram was generated by clustal W (http://www.ebi.ac.uk/Tools/msa/clustalw2/).