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M. fortuitum alters intracellular Ca+2homeostasis leading to activation of CaM and PKCα. PKCα induces superoxide anions generation via NADPH Oxidase. CaM and superoxide together activates CaMKIIg. In downstream, CaMKIIg modulates ERK1/2 to activate NOS2-NO axis. The ensuing ERK1/2-NO positive feedback loop leads to caspase-8 mediated caspase-3 activation and HKM apoptosis.
