Figure 5.
DNase I significantly inhibits fibrin generation in autonomous plasma from patients with stage III/IV GC. Autonomous plasma was incubated without or with DNase I, and fibrin formation was continually monitored after addition of CaCl2. A, B. The time to peak and peak turbidity of autonomous plasma derived from stage III/IV patients were significantly shorter and higher, respectively, than those from healthy controls. C, D. DNase I significantly prolonged the time to peak and reduced peak turbidity in patients with stage III/IV cancer. Each panel consists of the healthy controls (CTR, n = 36), patients in stage I (S-I, n = 7), stage II (S-II n = 9), stage III (S-III, n = 25) and stage IV (S-IV, n = 7) cancer. Data are represented as means ± SD. *P < 0.001. GC, gastric cancer; FGT, fibrin generation test.