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Line-1 hypomethylation confers poor prognosis in ESCC. The overall survival of these patients was compared using the Kaplan-Meier method and the log-rank test. Results showed a significantly longer median cumulative survival (43 months) was seen in ESCC with MI > 0.78 group compared with 34 months in the ESCC with MI ≤ 0.78 group (log-rank P < 0.0001).
