Table 1.

Correlation of clinicophthologic variables with Line-1 hypomethylation in ESCC

Variable		No.	MI ≤ 0.78 (N = 143)	MI > 0.78 (N = 167)	Odds ratio (95% CI)	P value*
Gender	Male	180	89	91	1.38 (0.87-2.17)	0.168
	Female	130	54	76
Age (y)	≥ 50	262	129	133	2.36 (1.21-4.59)	0.010
	< 50	48	14	34
Size	< 3 cm	172	86	86	1.42 (0.90-2.23)	0.127
	≥ 3 cm	138	57	81
Tobacco	Yes	168	83	85	1.34 (0.85-2.09)	0.208
	No	142	60	82
Alcohol	Yes	147	74	73	1.38 (0.88-2.16)	0.158
	No	163	69	94
Depth of invasion	T1-2	224	106	118	1.19 (0.72-1.96)	0.497
	T3-4	86	37	49
AJCC Stage	I-II	125	39	86	0.35 (0.22-0.57)	< 0.0001
	III-IV	185	104	81
Lymph node metastasis	N0-1	148	60	88	1.47 (0.97-2.24)	0.071
	N2-3	262	83	179
Distant metastasis	M0	251	123	128	1.40 (0.75-2.59)	0.294
	M1	59	20	29
Differentiation	G1	88	36	52		0.015
	G2	142	59	83
	G3	80	48	32

^*Comparison was done with Pearson’s Chi-square test or Fisher’s exact test.