Table 1.
Statistical analysis of factors predicting patients’ overall survival (OS)
| (Number of patients) | OS (months) | Univariate* | Multivariate** | |
|---|---|---|---|---|
|
|
||||
| Median | P Value | P Value | 95% CI | |
| Sex | ||||
| Male (44) | 23.0 | 0.035 | ||
| Female (21) | 41.0 | |||
| Age | ||||
| < 65 years (44) | 30.0 | 0.207 | ||
| ≥ 65 years (21) | 25.0 | |||
| Smoking Index | ||||
| < 400 (36) | 25.0 | 0.283 | ||
| ≥ 400 (29) | 30.0 | |||
| Surgical approach | ||||
| Lobectomy (47) | 37.3 | 0.001 | 0.002 | 0.156-0.669 |
| Pneumonectomy (18) | 15.0 | |||
| Clinical stage | ||||
| I (20) | 67.2 | 0.002 | ||
| II (15) | 17.1 | |||
| III (30) | 20.0 | |||
| Lymphatic metastasis | ||||
| Yes (26) | 20.0 | 0.001 | ||
| No (39) | 67.0 | |||
| VEGF | ||||
| + (33) | 31.0 | 0.423 | ||
| - (32) | 29.8 | |||
| N-cadherin | ||||
| + (23) | 31.0 | 0.781 | ||
| - (42) | 29.8 | |||
| CXCR4 | ||||
| + (31) | 19.0 | 0.004 | 0.003 | 1.447-5.963 |
| - (34) | 41.0 | |||
| MMP9 | ||||
| + (34) | 24.0 | 0.899 | ||
| - (31) | 34.0 | |||
| TGF-β1 | ||||
| + (28) | 31.0 | 0.142 | 0.035 | 0.220-0.946 |
| - (37) | 29.0 | |||
*
Univariate Analysis;
**
Multivariate Analysis.