. 2015 Nov 1;8(11):14853–14863.

Table 4.

Univariate and multivariate analysis of overall survival and disease free survival

	OS				DFS

Variable	Univariate	P-value	Mutivariate	P-value	Univariate	P-value	Mutivariate	P-value

	HR (95% CI)		HR (95% CI)		HR (95% CI)		HR (95% CI)
Age
< 65	1	0.053			1	0.070
≥ 65	1.543 (0.995-2.393)				1.486 (0.968-2.281)
Sex
Male	1	0.114			1	0.085
Female	0.710 (0.465-1.085)				0.693 (0.457-1.052)
Location
Colon	1	0.660			1	0.762
Rectum	0.909 (0.593-1.392)				0.937 (0.617-1.425)
Size
< 5 cm	1	0.007^*	1.634 (1.065-2.507)	0.024^*	1	0.004^*	1.696 (1.113-2.584)	0.014^*
≥ 5 cm	1.789 (1.169-2.738)				1.852 (1.218-2.815)
T stage
T1	1	0.053			1	0.037^*	1.129 (0.781-1.631)	0.520
T2	1.795 (0.393-8.193)				1.801 (0.395-8.221)
T3	3.578 (0.872-14.692)				3.855 (0.940-15.807)
T4	3.962 (0.934-16.809)				4.009 (0.945-17.007)
N stage
N0	1	0.001^*	1.528 (1,163-2.007)	0.002^*	1	0.001^*	1.514 (1.158-1.978)	0.002^*
N1	1.324 (0.810-2.164)				1.413 (0.877-2.277)
N2	2.881 (1.663-4.991)				2.805 (1.622-4.850)
AJCC stage
I	1	0.016^*	1.027 (0.611-1.726)	0.919	1	0.009^*	1.004 (0.529-1.904)	0.991
II	1.824 (0.901-3.692)				1.906 (0.944-3.849)
III	2.627 (1.320-5.229)				2.796 (1.409-5.548)
Differentiation
Well	1	0.001^*	2.129 (1.488-3.046)	< 0.001^*	1	0.002^*	2.032 (1.429-2.889)	< 0.001^*
Moderate	3.948 (1.429-10.910)				3.224 (1.290-8.054)
Poor	6.360 (2.239-18.061)				5.165 (2.003-13.317)
CEA (Negative vs. Positive)	2.099 (1.332-3.307)	0.001^*	1.460 (0.798-2.670)	0.219	1.968 (1.264-3.062)	0.003^*	1.358 (0.754-2.445)	0.308
CA19-9 (Negative vs. Positive)	1.997 (1.298-3.073)	0.002^*	1.139 (0.509-2.549)	0.751	1.902 (1247-2.900)	0.003^*	1.088 (0.485-2.441)	0.837
CA242 (Negative vs. Positive)	1.984 (1.303-3.021)	0.001^*	1.523 (0.741-3.131)	0.253	1.918 (1.269-2.900)	0.002^*	1.539 (0.748-3.165)	0.242
Combined 3 markers (Negative vs. Positive)	2.599 (1.441-4.688)	0.002^*	2.532 (1.400-4.579	0.002^*	2.446 (1.383-4,326)	0.002^*	2.366 (1.334-4.196)	0.003^*

P < 0.05.