Table 2.

Overall survival, univariate and multivariate analyses

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	p value	HR (95% CI)	p value
Age (years)		0.001*		0.008*,a
<57.5	reference		reference
≥57.5	2.66 (1.46-4.85)		2.39 (1.26-4.56)
Sex		0.110
Female	reference
Male	1.65 (0.89-3.04)
TNM stage		<0.001*		0.002*,a
I	reference		reference
II	2.68 (1.21-5.95)	0.015*	2.09 (0.86-5.12)	0.105a
III	11.13 (6.00-20.66)	<0.001*	4.46 (2.07-9.59)	<0.001*,a
IV	11.04 (2.57-47.33)	0.001*	2.40 (0.38-15.09)	0.351a
Tumor necrosis		<0.001*		0.982a
Absent	reference		reference
Present	3.26 (1.75-6.05)		1.01 (0.48-2.10)
Lymphovascular invasion		<0.001*		0.907a
Absent	reference		reference
Present	5.64 (2.74-11.60)		1.06 (0.40-2.78)
Hemoglobin (g/L)		<0.001*		0.001*,a
≥116.05	reference		reference
<116.05	5.89 (3.40-10.20)		2.74 (1.48-5.07)
Ca (mmol/L)		<0.001*		0.009*,a
≥2.40	reference		reference
<2.40	3.33 (1.80-6.19)		2.52 (1.26-5.05)
CRP/Alb ratio		<0.001*		<0.001*,a
<0.060	reference		reference
≥0.060 and <0.115	2.92 (1.01-8.42)	0.047*	3.13 (1.07-9.13)	0.037*,a
≥0.115	15.49 (6.06-39.62)	<0.001*	7.45 (2.81-19.73)	<0.001*,a
GPS		<0.001*		0.001*,b
0	reference		reference
1	6.64 (3.56-12.37)	<0.001*	3.57 (1.79-7.15)	<0.001*,b
2	13.26 (6.47-27.17)	<0.001*	2.540 (1.03-6.29)	0.044*,b
mGPS		<0.001*		0.019*,c
0	reference		reference
1	5.30 (2.65-10.59)	<0.001*	2.98 (1.36-6.53)	0.006*,c
2	10.96 (5.47-21.94)	<0.001*	1.94 (0.81-4.62)	0.135c

^*Indicates that the difference was statistically significant.

Abbreviation: HR Hazard ratio, CI confidence interval, TNM tumornode-metastasis, CRP/Alb the C-reactive protein/Albumin ratio, Ca calcium , GPS the Glasgow Prognostic Score, mGPS the modified Glasgow Prognostic Score.

^aAdjustment for age, TNM stage, tumor necrosis, lymphovascular invasion, hemoglobin, Ca, CRP/Alb ratio;

^bAdjustment for age, TNM stage, tumor necrosis, lymphovascular invasion, hemoglobin, Ca, GPS;

^cAdjustment for age, TNM stage, tumor necrosis, lymphovascular invasion, hemoglobin, Ca, mGPS.