Table 2.
Association between GSTP1 Ile105Val, XRCC1 Arg194Trp, Arg280His and Arg399Gln and response to chemotherapy in advanced NSCLC
| Genes | N | % | HWE | Good response | % | Poor response | % | OR (95% CI)1 | P value |
|---|---|---|---|---|---|---|---|---|---|
| GSTP1 Ile105Val | |||||||||
| AA | 91 | 44.17 | 36 | 33.96 | 55 | 55.00 | 1.0 (Ref.) | - | |
| AG | 94 | 45.63 | 54 | 50.94 | 40 | 40.00 | 2.06 (1.10-3.86) | 0.02 | |
| GG | 21 | 10.19 | 0.80 | 16 | 15.09 | 5 | 5.00 | 4.89 (1.52-18.33) | 0.002 |
| XRCC1 Arg194Trp | |||||||||
| CC | 94 | 45.63 | 41 | 38.68 | 53 | 53.00 | 1.0 (Ref.) | - | |
| CT | 84 | 40.78 | 45 | 42.45 | 39 | 39.00 | 1.49 (0.79-2.81) | 0.18 | |
| TT | 28 | 13.59 | 0.19 | 20 | 18.87 | 8 | 8.00 | 3.23 (1.20-9.30) | 0.01 |
| XRCC1 Arg280His | |||||||||
| AA | 104 | 50.49 | 51 | 48.11 | 53 | 53.00 | 1.0 (Ref.) | - | |
| AG | 79 | 38.35 | 40 | 37.74 | 39 | 39.00 | 1.07 (0.57-2.00) | 0.83 | |
| GG | 23 | 11.17 | 0.18 | 15 | 14.15 | 8 | 8.00 | 1.95 (0.70-5.76) | 0.16 |
| XRCC1 Arg399Gln | |||||||||
| GG | 91 | 44.17 | 44 | 41.51 | 47 | 47.00 | 1.0 (Ref.) | - | |
| GA | 83 | 40.29 | 41 | 38.68 | 42 | 42.00 | 1.04 (0.55-1.97) | 0.89 | |
| AA | 32 | 15.53 | 0.08 | 21 | 19.81 | 11 | 11.00 | 2.04 (0.82-5.23) | 0.09 |
1
Ajusted for age, gender, smoking status, drinking status, TNM stage and histology.