Table 3.
Association between GSTP1 Ile105Val, XRCC1 Arg194Trp, Arg280His and Arg399Gln and overall survival of patients with advanced NSCLC
| Genes | N | % | Death N=166 | % | Alive | % | Mean survival time | P value for Log-rank test | Adjusted HR (95% CI)1 | P value |
|---|---|---|---|---|---|---|---|---|---|---|
| GSTP1 Ile105Val | ||||||||||
| AA | 91 | 44.17 | 81 | 48.80 | 10 | 25.00 | 19.43±1.62 | 1.0 (Ref.) | - | |
| AG | 94 | 45.63 | 79 | 47.59 | 15 | 37.50 | 21.27±1.49 | 0.65 (0.25-1.66) | 0.32 | |
| GG | 21 | 10.19 | 6 | 3.61 | 15 | 37.50 | 42.76±4.28 | <0.001 | 0.05 (0.01-0.18) | <0.001 |
| XRCC1 Arg194Trp | ||||||||||
| CC | 94 | 45.63 | 83 | 50.00 | 11 | 27.50 | 22.39±1.63 | 1.0 (Ref.) | - | |
| CT | 84 | 40.78 | 66 | 39.76 | 18 | 45.00 | 24.07±2.02 | 0.49 (0.19-1.18) | 0.08 | |
| TT | 28 | 13.59 | 17 | 10.24 | 11 | 27.50 | 30.73±3.02 | 0.01 | 0.20 (0.07-0.62) | <0.001 |
| XRCC1 Arg280His | ||||||||||
| AA | 104 | 50.49 | 84 | 50.60 | 20 | 50.00 | 23.63±1.65 | 1.0 (Ref.) | - | |
| AG | 79 | 38.35 | 66 | 39.76 | 13 | 32.50 | 21.20±1.77 | 1.21 (0.53-2.85) | 0.63 | |
| GG | 23 | 11.17 | 16 | 9.64 | 7 | 17.50 | 25.12±3.17 | 0.25 | 0.54 (0.18-1.79) | 0.23 |
| XRCC1 Arg399Gln | ||||||||||
| GG | 91 | 44.17 | 73 | 43.98 | 18 | 45.00 | 22.48±1.87 | 1.0 (Ref.) | - | |
| GA | 83 | 40.29 | 71 | 42.77 | 12 | 30.00 | 24.55±1.74 | 1.45 (0.61-3.57) | 0.35 | |
| AA | 32 | 15.53 | 22 | 13.25 | 10 | 25.00 | 26.24±1.95 | 0.18 | 0.54 (0.20-1.52) | 0.18 |
1
Ajusted for age, gender, smoking status, drinking status, TNM stage and histology.