Table 5.
Interaction between GSTP1 Ile105Val and XRCC1 Arg194Trp in the overall survival of advanced NSCLC
| Genes | N | % | Death | % | Alive | % | Mean survival time | Adjusted HR (95% CI)1 | P value | |
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| GSTP1 Ile105Val | XRCC1 Arg194Trp | |||||||||
| AA | CC | 58 | 28.16 | 54 | 32.53 | 4 | 10.00 | 20.27±1.16 | 1.0 (Reference) | - |
| GA+GG | CC | 37 | 17.96 | 29 | 17.47 | 8 | 20.00 | 22.92±1.07 | 0.27 (0.06-1.12) | 0.06 |
| GA+GG | CT+TT | 78 | 37.86 | 56 | 33.73 | 22 | 55.00 | 23.57±1.14 | 0.19 (0.05-0.61) | 0.002 |
| AA | CT+TT | 33 | 16.02 | 27 | 16.27 | 6 | 15.00 | 21.56±1.11 | 0.33 (0.06-1.56) | 0.10 |
1
Ajusted for age, gender, smoking status, drinking status, TNM stage and histology.