Appendix Table 3.
Sensitivity analysis of the racial disparity in placental pathological lesions, with term (37-42 week) births included only, the Collaborative Perinatal Project, 1959-1966
| Placenta pathological lesions | White Race | African-American | Crude OR | Adjusted OR1 | Adjusted OR2 |
|---|---|---|---|---|---|
| N | 16,157 (57.2) | 12,069 (42.8) | / | / | / |
| Placental weight | |||||
| Placental weight < 10th | 1,138 (7.1) | 1,295 (10.8) | 1.6 (1.5, 1.7) | 1.4 (1.2, 1.5) | 1.4 (1.2, 1.6) |
| PBW ratio > 90th | 1,235 (7.7) | 1,198 (10.0) | 1.3 (1.2, 1.4) | 1.2 (1.0, 1.3) | 1.1 (1.0, 1.3) |
| Vascular lesions of maternal origin | |||||
| Infarcts in the cut surface | |||||
| Occurrence of vascular infarcts | 2,833 (17.5) | 1,290 (10.7) | 0.6 (0.5, 0.6) | 0.8 (0.7, 0.9) | 0.8 (0.7, 0.9) |
| Infarct size | 729 (4.5) | 280 (2.3) | 0.5 (0.5, 0.6) | 0.7 (0.6, 0.9) | 0.7 (0.6, 0.9) |
| Number of infarcts | 971 (6.0) | 346 (2.9) | 0.5 (0.4, 0.5) | 0.8 (0.7, 1.0) | 0.8 (0.6, 1.0) |
| Thrombosis in the cut surface | 1,326 (8.2) | 347 (2.9) | 0.3 (0.3, 0.4) | 0.8 (0.7, 0.9) | 0.9 (0.7, 1.1) |
| Vessel fibroid in the decidua | 312 (2.0) | 198 (1.7) | 0.9 (0.7, 1.0) | 1.1 (0.9, 1.4) | 1.1 (0.8, 1.4) |
| Villous lesions of maternal origin | |||||
| Villous infarcts in the intervillous space | 2,361 (14.6) | 1,743 (14.5) | 1.0 (0.9, 1.1) | 0.8 (0.7, 0.9) | 0.8 (0.7, 0.9) |
| Syncytium-Nuclear clumping in the decidua | 468 (3.2) | 173 (1.6) | 0.5 (0.4, 0.6) | 0.9 (0.7, 1.2) | 0.9 (0.7, 1.2) |
| Vascular lesions of fetal origin | 137 (0.9) | 104 (0.9) | 1.0 (0.7, 1.3) | 1.4 (0.9, 2.1) | 1.4 (0.9, 2.2) |
| Villous lesions of fetal origin | |||||
| Stromal fibrosis in the terminal villi | 295 (1.8) | 107 (0.9) | 0.5 (0.4, 0.6) | 0.6 (0.5, 0.9) | 0.7 (0.5, 1.0) |
| Langerhans layer in the terminal villi | 83 (0.5) | 59 (0.5) | 1.0 (0.7, 1.3) | 0.7 (0.4, 1.1) | 0.6 (0.4, 1.0) |
| Marginal insertion of cord | 790 (4.9) | 346 (2.9) | 0.6 (0.5, 0.7) | 0.6 (0.5, 0.7) | 0.6 (0.5, 0.8) |
| Calcification throughout the cut surface | 1,944 (27.6) | 1,275 (16.6) | 0.9 (0.8, 0.9) | 0.9 (0.8, 1.0) | 0.9 (0.8, 1.0) |
| Hemorrhage | |||||
| Occurrence of hemorrhage | 1301 (8.1) | 695 (5.8) | 0.7 (0.6, 0.8) | 1.0 (0.8, 1.1) | 0.9 (0.8, 1.1) |
| Old hemorrhage in the maternal surface | 1272 (7.9) | 464 (3.8) | 0.8 (0.7, 0.9) | 1.1 (0.9, 1.4) | 1.1 (0.9, 1.4) |
| Thrombosis in the intervillous space | 2,196 (13.6) | 818 (6.8) | 0.5 (0.4, 0.5) | 0.7 (0.7, 0.8) | 0.7 (0.7, 0.8) |
| Inflammatory cell infiltration | |||||
| Fetal neutrophilic infiltration | 787 (4.9) | 520 (4.3) | 0.9 (0.8, 1.0) | 1.1 (0.9, 1.3) | 1.1 (0.9, 1.3) |
| Maternal neutrophilic infiltration | 1,148 (7.1) | 1,017 (8.4) | 1.2 (1.1, 1.3) | 1.1 (1.0, 1.3) | 1.1 (0.9, 1.2) |
| Maternal lymphocytic infiltration | 126 (0.8) | 139 (1.2) | 1.5 (1.2, 1.9) | 1.3 (0.9, 1.9) | 1.4 (0.9, 2.1) |
| Meconium | 991 (6.2) | 1,256 (10.5) | 1.8 (1.6, 1.9) | 1.2 (1.0, 1.3) | 1.2 (1.0, 1.3) |
PBW ratio: Placenta-to-birthweight ratio. Model 1. Unadjusted logistic model. Model 2. Logistic model adjusted by maternal age, education levels, marital status, parity, social economic status, gestational age, maternal prepregnancy body mass index, and study center, with reference group of White race. Model 3. Pregnancy associated hypertension and diabetes excluded on the basis of adjusted model above. Bold font: P < 0.05.